What are some frequently asked questions about depression?

Will depression go away on its own?

Depression is not something that you can just “snap out of.” It is a disorder that requires medical attention and treatment. If left untreated, it can last for months or even years. In order to help you get better, your doctor may prescribe Viibryd®.

What causes depression?

It is widely believed that depression probably results from a combination of genetic, biochemical, environmental, and psychological factors. Research suggests that environmental and genetic factors, such as family history of depression, may make a person more likely to develop this disorder.

Medical experts believe that an imbalance of certain chemicals in the brain can cause symptoms of depression. A person can suffer from episodes of depression that can last for months or years.

What are the typical symptoms of depression?

A person with depression has at least 5 of the following symptoms:

  • Depressed mood
  • Loss of interest or pleasure
  • Feelings of worthlessness or guilt
  • Agitation or restlessness
  • Fatigue or loss of energy
  • Trouble thinking, making decisions, or concentrating
  • Disturbed sleep, such as insomnia
  • Changes in appetite or weight
  • Thoughts of death or suicide, or suicide attempts

At least one of the symptoms must be depressed mood or loss of interest or pleasure. These symptoms must be present during the same 2-week period and represent a change from previous functioning.

How do I know if I am depressed?

If you are an adult and think you may be suffering from depression, talk with your healthcare provider. He or she will be able to properly diagnose your condition and help you find the appropriate treatment.

What are some treatment options for depression?

The two major approaches to treating depression are psychotherapy and antidepressant medications. The approaches can be used alone or together. Counseling can provide new ways to cope with problems and help patients further understand the effect that depression has on them. And while the exact way medications for depression work is unknown, they are thought to affect the levels of certain chemicals in the brain.

What if I'm already on a medication for depression and still don't feel right... are there other treatment options for me?

The good news is that there are many treatment options available. Your healthcare provider may try different doses of your current medication or try another medication before finding the one that's right for you. It's important for you to partner with your healthcare provider and work toward getting an appropriate treatment for your depression. If you need help with that discussion, visit our section about Talking With Your Doctor.

Next: Talking With Your Doctor ►

Indication and Usage

VIIBRYD® (vilazodone HCI) is a prescription medicine indicated for the treatment of major depressive disorder (MDD) in adults.

Important Risk Information
What is the most important information I should know about VIIBRYD?

VIIBRYD and other antidepressant medicines may cause serious side effects. Call your healthcare provider right away if you have any of the symptoms described below, or call 911 if there is an emergency.

WARNING: SUICIDAL THOUGHTS AND BEHAVIORS

Antidepressants increased the risk of suicidal thoughts or actions in some people 24 years of age and younger. Watch closely for worsening depression and for suicidal thoughts and behaviors. Call your healthcare provider right away if you notice any new or sudden changes in mood, behavior, thoughts or feelings. Pay particular attention when VIIBRYD is started or when the dose is changed.

VIIBRYD is not approved for use in patients under 18.

Call your healthcare provider right away if you have any of these symptoms, especially if they are new, worse, or worry you:

  • Attempts to commit suicide; acting on dangerous impulses; acting aggressive or violent; thoughts about suicide or dying; new or worse depression, anxiety, or panic attacks; feeling agitated, restless, angry or irritable; trouble sleeping; an increase in activity or talking more than normal (mania); or other unusual changes in behavior or mood

Serotonin Syndrome: Agitation, hallucinations, coma or other changes in mental status; coordination problems or muscle twitching; fast heartbeat, high or low blood pressure; sweating or fever; nausea, vomiting or diarrhea; muscle stiffness or tightness.

Increased chance of bleeding: VIIBRYD and other antidepressant medicines may increase your chance of bleeding or bruising, especially if you take the blood thinner warfarin (Coumadin®, Jantoven®), a non-steroidal anti-inflammatory drug (NSAID), or aspirin.

Manic episodes: Greatly increased energy; severe trouble sleeping; racing thoughts; reckless behavior; unusually grand ideas; excessive happiness or irritability; talking more or faster than usual.

Discontinuation symptoms: Do not suddenly stop VIIBRYD without first talking to your healthcare provider. Stopping VIIBRYD suddenly may cause serious symptoms including: flu-like symptoms (eg, headache, sweating, nausea); anxiety, high or low mood, irritability, feeling restless or sleepy; dizziness, electric shock-like sensations, tremor, and confusion.

Seizures or convulsions.

Glaucoma (angle-closure glaucoma): Many antidepressants, including VIIBRYD, may cause an eye problem called angle-closure glaucoma. Call your healthcare provider if you have changes in your vision or eye pain.

Low salt (sodium) levels in the blood: Elderly people may be at greater risk for this. Symptoms may include headache; weakness or feeling unsteady; confusion, problems concentrating or thinking or memory problems.

Who should not take VIIBRYD?
  • Do not take any drugs known as monoamine oxidase inhibitors (MAOIs), including linezolid (an antibiotic), with VIIBRYD or within 14 days of stopping VIIBRYD
  • Do not start VIIBRYD if you started or stopped taking an MAOI in the last 14 days

People who take VIIBRYD close in time to taking an MAOI may have serious or even life-threatening side effects.

What should I tell my healthcare provider before taking VIIBRYD?
  • Tell your healthcare provider about any medical conditions or if you:
    • Have liver or kidney problems
    • Have or had mania, bipolar disorder (manic depression), seizures or convulsions
    • Have or had bleeding problems. VIIBRYD may increase your chance of bleeding or bruising
    • Have low salt (sodium) levels in your blood or are taking diuretics (water pills)
    • Drink alcohol
    • Are pregnant, breastfeeding or are planning to become pregnant or to breastfeed
  • Tell your healthcare provider about all prescription, over-the-counter medications, vitamins, and herbal supplements you are taking or plan to take, especially:
    • Triptans used to treat migraine headaches; medicines used to treat mood, anxiety, psychotic or thought disorders, including tricyclics, lithium, SSRIs, SNRIs, buspirone, amphetamines, or antipsychotics; tramadol, mephenytoin (Mesantoin) or over-the-counter supplements such as tryptophan or St. John’s Wort; this is necessary to avoid a potentially life-threatening condition
    • Aspirin, NSAID pain relievers, or blood thinners (eg, warfarin, Coumadin, or Jantoven) because they may increase the risk of bleeding
    • Diuretics (water pills)
What should I avoid when taking VIIBRYD?
  • Until you know how VIIBRYD affects you, you should not drive, operate heavy machinery, or engage in other dangerous activities. Avoid drinking alcohol while taking VIIBRYD.
What are the most common side effects of VIIBRYD?
  • The most common side effects in people taking VIIBRYD include diarrhea, nausea or vomiting, and trouble sleeping.
  • Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of VIIBRYD. For more information, ask your healthcare provider or pharmacist.

Call your doctor for medical advice about side effects.

Please also see Medication Guide within the full Prescribing Information.

Important Risk Information
What is the most important information I should know about VIIBRYD?

VIIBRYD and other antidepressant medicines may cause serious side effects. Call your healthcare provider right away if you have any of the symptoms described below, or call 911 if there is an emergency.

WARNING: SUICIDAL THOUGHTS AND BEHAVIORS

Antidepressants increased the risk of suicidal thoughts or actions in some people 24 years of age and younger. Watch closely for worsening depression and for suicidal thoughts and behaviors. Call your healthcare provider right away if you notice any new or sudden changes in mood, behavior, thoughts or feelings. Pay particular attention when VIIBRYD is started or when the dose is changed.

VIIBRYD is not approved for use in patients under 18.

Call your healthcare provider right away if you have any of these symptoms, especially if they are new, worse, or worry you:

  • Attempts to commit suicide; acting on dangerous impulses; acting aggressive or violent; thoughts about suicide or dying; new or worse depression, anxiety, or panic attacks; feeling agitated, restless, angry or irritable; trouble sleeping; an increase in activity or talking more than normal (mania); or other unusual changes in behavior or mood

Serotonin Syndrome: Agitation, hallucinations, coma or other changes in mental status; coordination problems or muscle twitching; fast heartbeat, high or low blood pressure; sweating or fever; nausea, vomiting or diarrhea; muscle stiffness or tightness.

Increased chance of bleeding: VIIBRYD and other antidepressant medicines may increase your chance of bleeding or bruising, especially if you take the blood thinner warfarin (Coumadin®, Jantoven®), a non-steroidal anti-inflammatory drug (NSAID), or aspirin.

Manic episodes: Greatly increased energy; severe trouble sleeping; racing thoughts; reckless behavior; unusually grand ideas; excessive happiness or irritability; talking more or faster than usual.

Discontinuation symptoms: Do not suddenly stop VIIBRYD without first talking to your healthcare provider. Stopping VIIBRYD suddenly may cause serious symptoms including: flu-like symptoms (eg, headache, sweating, nausea); anxiety, high or low mood, irritability, feeling restless or sleepy; dizziness, electric shock-like sensations, tremor, and confusion.

Seizures or convulsions.

Glaucoma (angle-closure glaucoma): Many antidepressants, including VIIBRYD, may cause an eye problem called angle-closure glaucoma. Call your healthcare provider if you have changes in your vision or eye pain.

Low salt (sodium) levels in the blood: Elderly people may be at greater risk for this. Symptoms may include headache; weakness or feeling unsteady; confusion, problems concentrating or thinking or memory problems.

Who should not take VIIBRYD?
  • Do not take any drugs known as monoamine oxidase inhibitors (MAOIs), including linezolid (an antibiotic), with VIIBRYD or within 14 days of stopping VIIBRYD
  • Do not start VIIBRYD if you started or stopped taking an MAOI in the last 14 days

People who take VIIBRYD close in time to taking an MAOI may have serious or even life-threatening side effects.

What should I tell my healthcare provider before taking VIIBRYD?
  • Tell your healthcare provider about any medical conditions or if you:
    • Have liver or kidney problems
    • Have or had mania, bipolar disorder (manic depression), seizures or convulsions
    • Have or had bleeding problems. VIIBRYD may increase your chance of bleeding or bruising
    • Have low salt (sodium) levels in your blood or are taking diuretics (water pills)
    • Drink alcohol
    • Are pregnant, breastfeeding or are planning to become pregnant or to breastfeed
  • Tell your healthcare provider about all prescription, over-the-counter medications, vitamins, and herbal supplements you are taking or plan to take, especially:
    • Triptans used to treat migraine headaches; medicines used to treat mood, anxiety, psychotic or thought disorders, including tricyclics, lithium, SSRIs, SNRIs, buspirone, amphetamines, or antipsychotics; tramadol, mephenytoin (Mesantoin) or over-the-counter supplements such as tryptophan or St. John’s Wort; this is necessary to avoid a potentially life-threatening condition
    • Aspirin, NSAID pain relievers, or blood thinners (eg, warfarin, Coumadin, or Jantoven) because they may increase the risk of bleeding
    • Diuretics (water pills)
What should I avoid when taking VIIBRYD?
  • Until you know how VIIBRYD affects you, you should not drive, operate heavy machinery, or engage in other dangerous activities. Avoid drinking alcohol while taking VIIBRYD.
What are the most common side effects of VIIBRYD?
  • The most common side effects in people taking VIIBRYD include diarrhea, nausea or vomiting, and trouble sleeping.
  • Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of VIIBRYD. For more information, ask your healthcare provider or pharmacist.

Call your doctor for medical advice about side effects.

Please also see Medication Guide within the full Prescribing Information.