What are some frequently asked questions about depression?

Will depression go away on its own?

Depression is not something that you can just “snap out of.” It is a disorder that requires medical attention and treatment. If left untreated, it can last for months or even years. In order to help you get better, your doctor may prescribe Viibryd®.

What causes depression?

It is widely believed that depression probably results from a combination of genetic, biochemical, environmental, and psychological factors. Research suggests that environmental and genetic factors, such as family history of depression, may make a person more likely to develop this disorder.

Medical experts believe that an imbalance of certain chemicals in the brain can cause symptoms of depression. A person can suffer from episodes of depression that can last for months or years.

What are the typical symptoms of depression?

A person with depression has at least 5 of the following symptoms:

  • Depressed mood
  • Loss of interest or pleasure
  • Feelings of worthlessness or guilt
  • Agitation or restlessness
  • Fatigue or loss of energy
  • Trouble thinking, making decisions, or concentrating
  • Disturbed sleep, such as insomnia
  • Changes in appetite or weight
  • Thoughts of death or suicide, or suicide attempts

At least one of the symptoms must be depressed mood or loss of interest or pleasure. These symptoms must be present during the same 2-week period and represent a change from previous functioning.

How do I know if I am depressed?

If you are an adult and think you may be suffering from depression, talk with your healthcare provider. He or she will be able to properly diagnose your condition and help you find the appropriate treatment.

What are some treatment options for depression?

The two major approaches to treating depression are psychotherapy and antidepressant medications. The approaches can be used alone or together. Counseling can provide new ways to cope with problems and help patients further understand the effect that depression has on them. And while the exact way medications for depression work is unknown, they are thought to affect the levels of certain chemicals in the brain.

What if I'm already on a medication for depression and still don't feel right... are there other treatment options for me?

The good news is that there are many treatment options available. Your healthcare provider may try different doses of your current medication or try another medication before finding the one that's right for you. It's important for you to partner with your healthcare provider and work toward getting an appropriate treatment for your depression. If you need help with that discussion, visit our section about Talking With Your Doctor.

Next: Talking With Your Doctor ►

Indication and Usage

VIIBRYD® (vilazodone HCI) is a prescription medicine indicated for the treatment of major depressive disorder (MDD) in adults.

Important Risk Information
What is the most important information I should know about VIIBRYD?

VIIBRYD and other antidepressants may increase suicidal thoughts or actions in some people 24 years of age and younger, especially within the first few months of treatment or when the dose is changed. VIIBRYD is not for use in children.

Depression or other serious mental illnesses are the most important causes of suicidal thoughts or actions. Some people, including those with (or a family history of) depression, bipolar illness, or a history of suicidal thoughts or actions may have a higher risk of suicidal thoughts or actions. Pay close attention to and call your healthcare provider right away to report any new or sudden changes in mood, behavior, thoughts or feelings.

Call your healthcare provider right away if you have any of these symptoms, especially if they are new, worse, or worry you:

  • Attempts to commit suicide; acting on dangerous impulses; acting aggressive or violent; thoughts about suicide or dying; new or worse depression, new or worse anxiety; panic attacks; feeling agitated or restless; new or worse irritability; trouble sleeping; an extreme increase in activity or talking (mania); or other unusual changes in behavior or mood
Who should not take VIIBRYD?

Do not take VIIBRYD if you take a monoamine oxidase inhibitor (MAOI), have taken or will take an MAOI within 14 days of taking VIIBRYD, or are being treated with the antibiotic linezolid or intravenous methylene blue.

VIIBRYD may cause other serious side effects, including:

Serotonin Syndrome: A potentially life-threatening problem that can happen when VIIBRYD is taken with certain other medicines. Stop taking VIIBRYD and call your healthcare provider or go to the nearest emergency room right away if you have any of the following: agitation; hallucinations; confusion, coma; fast heart beat; blood pressure changes; dizziness; sweating; flushing; high body temperature; tremors, stiff muscles, or muscle twitching; loss of coordination; seizures; nausea, vomiting or diarrhea

Increased chance of bleeding: Taking VIIBRYD with aspirin, non-steroidal anti-inflammatory drugs (NSAIDs), warfarin, or blood thinners may add to this risk. Tell your healthcare provider right away about unusual bleeding or bruising

Manic episodes: Symptoms may include greatly increased energy; severe trouble sleeping; racing thoughts; reckless behavior; unusually grand ideas; excessive happiness or irritability; talking more or faster than usual

Discontinuation symptoms: Do not suddenly stop VIIBRYD without first talking to your healthcare provider. Stopping VIIBRYD suddenly may cause serious side effects including: nausea; sweating; changes in mood; headache; irritability and agitation; tiredness; dizziness; problems sleeping; electric shock sensation; hypomania; anxiety; ringing in your ears; confusion; seizures

Seizures or convulsions

Glaucoma (angle-closure glaucoma): VIIBRYD may cause an eye problem called angle-closure glaucoma. Call your healthcare provider if you have changes in your vision or eye pain

Low salt (sodium) levels in the blood: May be serious and may cause death. Elderly people may be at greater risk for this. Symptoms may include headache; difficulty concentrating; memory changes; confusion; weakness and unsteadiness which can lead to falls

In severe or more sudden cases, symptoms include hallucinations; fainting; seizures; coma; respiratory arrest; death.

What should I tell my healthcare provider before taking VIIBRYD?
  • Tell your healthcare provider about any medical conditions or if you:
    • Have or have a family history of suicide, depression, bipolar disorder, mania or hypomania
    • Have or had bleeding problems
    • Have or had seizures or convulsions
    • Have high pressure in the eye (glaucoma)
    • Have low salt (sodium) levels in your blood
    • Drink alcohol
    • Are pregnant or plan to become pregnant. Taking VIIBRYD late in pregnancy may lead to an increased risk of certain problems in your newborn. Talk to your healthcare provider about the risks to your baby if you take VIIBRYD during pregnancy. If you become pregnant during treatment with VIIBRYD, talk to your healthcare provider about registering with the National Pregnancy Registry for Antidepressants at 1-844-405-6185
    • Are breastfeeding or plan to breastfeed. It is not known if VIIBRYD passes into breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment with VIIBRYD
  • Tell your healthcare provider about all prescription and over-the-counter medications, vitamins, and herbal supplements you are taking or plan to take, especially:
    • MAOIs; triptans (medicines used to treat migraines); tricyclic antidepressants; fentanyl; lithium; tramadol; tryptophan; buspirone; amphetamines; St. John’s Wort; medicines that can affect blood clotting such as aspirin, NSAIDs, and warfarin; diuretics; medicines used to treat mood, anxiety, psychotic, or thought disorders, including selective serotonin reuptake inhibitors (SSRIs) and serotonin norepinephrine reuptake inhibitors (SNRIs)
    • VIIBRYD may affect the way other medicines work, and other medicines may affect how VIIBRYD works. Do not start or stop any medicines while taking VIIBRYD without talking to your healthcare provider.
What should I avoid when taking VIIBRYD?
  • Do not drive, operate heavy machinery, or engage in other dangerous activities until you know how VIIBRYD affects you. VIIBRYD can cause sleepiness or may affect your ability to make decisions, think clearly, or react quickly. Avoid drinking alcohol while taking VIIBRYD.
What are the most common side effects of VIIBRYD?
  • The most common side effects of VIIBRYD include diarrhea, nausea or vomiting, and trouble sleeping. These are not all the possible side effects of VIIBRYD.

Call your doctor for medical advice about side effects.

Please also see Medication Guide within the full Prescribing Information.

Important Risk Information
What is the most important information I should know about VIIBRYD?

VIIBRYD and other antidepressants may increase suicidal thoughts or actions in some people 24 years of age and younger, especially within the first few months of treatment or when the dose is changed. VIIBRYD is not for use in children.

Depression or other serious mental illnesses are the most important causes of suicidal thoughts or actions. Some people, including those with (or a family history of) depression, bipolar illness, or a history of suicidal thoughts or actions may have a higher risk of suicidal thoughts or actions. Pay close attention to and call your healthcare provider right away to report any new or sudden changes in mood, behavior, thoughts or feelings.

Call your healthcare provider right away if you have any of these symptoms, especially if they are new, worse, or worry you:

  • Attempts to commit suicide; acting on dangerous impulses; acting aggressive or violent; thoughts about suicide or dying; new or worse depression, new or worse anxiety; panic attacks; feeling agitated or restless; new or worse irritability; trouble sleeping; an extreme increase in activity or talking (mania); or other unusual changes in behavior or mood
Who should not take VIIBRYD?

Do not take VIIBRYD if you take a monoamine oxidase inhibitor (MAOI), have taken or will take an MAOI within 14 days of taking VIIBRYD, or are being treated with the antibiotic linezolid or intravenous methylene blue.

VIIBRYD may cause other serious side effects, including:

Serotonin Syndrome: A potentially life-threatening problem that can happen when VIIBRYD is taken with certain other medicines. Stop taking VIIBRYD and call your healthcare provider or go to the nearest emergency room right away if you have any of the following: agitation; hallucinations; confusion, coma; fast heart beat; blood pressure changes; dizziness; sweating; flushing; high body temperature; tremors, stiff muscles, or muscle twitching; loss of coordination; seizures; nausea, vomiting or diarrhea

Increased chance of bleeding: Taking VIIBRYD with aspirin, non-steroidal anti-inflammatory drugs (NSAIDs), warfarin, or blood thinners may add to this risk. Tell your healthcare provider right away about unusual bleeding or bruising

Manic episodes: Symptoms may include greatly increased energy; severe trouble sleeping; racing thoughts; reckless behavior; unusually grand ideas; excessive happiness or irritability; talking more or faster than usual

Discontinuation symptoms: Do not suddenly stop VIIBRYD without first talking to your healthcare provider. Stopping VIIBRYD suddenly may cause serious side effects including: nausea; sweating; changes in mood; headache; irritability and agitation; tiredness; dizziness; problems sleeping; electric shock sensation; hypomania; anxiety; ringing in your ears; confusion; seizures

Seizures or convulsions

Glaucoma (angle-closure glaucoma): VIIBRYD may cause an eye problem called angle-closure glaucoma. Call your healthcare provider if you have changes in your vision or eye pain

Low salt (sodium) levels in the blood: May be serious and may cause death. Elderly people may be at greater risk for this. Symptoms may include headache; difficulty concentrating; memory changes; confusion; weakness and unsteadiness which can lead to falls

In severe or more sudden cases, symptoms include hallucinations; fainting; seizures; coma; respiratory arrest; death.

What should I tell my healthcare provider before taking VIIBRYD?
  • Tell your healthcare provider about any medical conditions or if you:
    • Have or have a family history of suicide, depression, bipolar disorder, mania or hypomania
    • Have or had bleeding problems
    • Have or had seizures or convulsions
    • Have high pressure in the eye (glaucoma)
    • Have low salt (sodium) levels in your blood
    • Drink alcohol
    • Are pregnant or plan to become pregnant. Taking VIIBRYD late in pregnancy may lead to an increased risk of certain problems in your newborn. Talk to your healthcare provider about the risks to your baby if you take VIIBRYD during pregnancy. If you become pregnant during treatment with VIIBRYD, talk to your healthcare provider about registering with the National Pregnancy Registry for Antidepressants at 1-844-405-6185
    • Are breastfeeding or plan to breastfeed. It is not known if VIIBRYD passes into breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment with VIIBRYD
  • Tell your healthcare provider about all prescription and over-the-counter medications, vitamins, and herbal supplements you are taking or plan to take, especially:
    • MAOIs; triptans (medicines used to treat migraines); tricyclic antidepressants; fentanyl; lithium; tramadol; tryptophan; buspirone; amphetamines; St. John’s Wort; medicines that can affect blood clotting such as aspirin, NSAIDs, and warfarin; diuretics; medicines used to treat mood, anxiety, psychotic, or thought disorders, including selective serotonin reuptake inhibitors (SSRIs) and serotonin norepinephrine reuptake inhibitors (SNRIs)
    • VIIBRYD may affect the way other medicines work, and other medicines may affect how VIIBRYD works. Do not start or stop any medicines while taking VIIBRYD without talking to your healthcare provider.
What should I avoid when taking VIIBRYD?
  • Do not drive, operate heavy machinery, or engage in other dangerous activities until you know how VIIBRYD affects you. VIIBRYD can cause sleepiness or may affect your ability to make decisions, think clearly, or react quickly. Avoid drinking alcohol while taking VIIBRYD.
What are the most common side effects of VIIBRYD?
  • The most common side effects of VIIBRYD include diarrhea, nausea or vomiting, and trouble sleeping. These are not all the possible side effects of VIIBRYD.

Call your doctor for medical advice about side effects.

Please also see Medication Guide within the full Prescribing Information.